ProZinc ™ (protamine zinc recombinant human insulin)

Clinically proven: the research

Reducing excessive urination and thirst

In a clinical study, diabetic cats showed significant improvement in excessive urination
and thirst within just 45 days on PROZINC.1

excessive urination

PROZINC works fast
About half of the cats in this study showed improvement within seven days2

By day 45:

  • Excessive urination improved in 74% of cats.1
  • Excessive thirst improved in 76% of cats.1

In addition to hypoglycemia, the following clinical observations were reported during the study: vomiting, lethargy, cystitis/hematuria, upper respiratory infection, dry coat, hair loss, ocular discharge, abnormal vocalization, black stool and rapid breathing. See Safety Info page for more information.

 

Improving body weight

In a clinical study, diabetic cats showed significant improvement in body condition within just 45 days on PROZINC.3

Body weight

By day 45:

  • Average body weight of cats on PROZINC increased from 11.9 pounds at the start of the study to 13 pounds.3
  • 89% of cats were determined by their veterinarians to be in good body condition.3

In addition to hypoglycemia, the following clinical observations were reported during the study: vomiting, lethargy, cystitis/hematuria, upper respiratory infection, dry coat, hair loss, ocular discharge, abnormal vocalization, black stool and rapid breathing. See Safety Info page for more information.

 

Reducing blood glucose levels

In a clinical study, diabetic cats showed significant improvement in blood glucose levels within just 45 days on PROZINC.

Glucose

By day 45:

  • 74% of cats had an average blood glucose lower than 300 mg/dL.2
  • Average blood glucose nadir (daily low) dropped from 408 to 142 mg/dL.1,4

In a 45-day effectiveness field study, 176 cats received PROZINC insulin. Hypoglycemia (defined as a blood glucose value of < 50 mg/dL) occurred in 71 of the cats at various times throughout the study. Clinical signs of hypoglycemia were generally mild in nature (described as lethargic, sluggish, weak, trembling, uncoordinated, groggy, glassy-eyed or dazed). See Safety Info page for more information.

 

Reducing fructosamine levels

In a clinical study, diabetic cats showed significant improvement in fructosamine levels within just 45 days on PROZINC.

Fructosamine
  • Average fructosamine level dropped from 506 to 381 μmol/L by day 45 and continued to decrease over the next 136 days.1,4
  • Based on fructosamine, 75% of cats were considered to be in good or excellent glycemic control after 181 days of treatment.2

In a 45-day effectiveness field study, 176 cats received PROZINC insulin. Hypoglycemia (defined as a blood glucose value of < 50 mg/dL) occurred in 71 of the cats at various times throughout the study. Clinical signs of hypoglycemia were generally mild in nature (described as lethargic, sluggish, weak, trembling, uncoordinated, groggy, glassy-eyed or dazed). See Safety Info page for more information.

 

1FOI for NADA 141-297. (PROZINC)

2Data on file. St. Joseph, MO: Boehringer Ingelheim Vetmedica.

3Nelson RW, Henley K, Cole C, et al. Field safety and efficacy of protamine zinc recombinant human insulin for treatment of diabetes mellitus in cats. J Vet Intern Med. 2009;23:787-793.

4PROZINC Product Insert