How can PROZINC help?

How can PROZINC help?

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PROZINC offers reliable, lasting results.

PROZINC is a protamine zinc insulin -- ideal for diabetic cats -- with a convenient duration of 10-14 hours.1 It releases slowly to help maintain a consistent blood glucose level throughout the day.

It's formulated just for cats.

Backed by extensive clinical studies, PROZINC is specifically designed for feline diabetes and is the first protamine zinc insulin with FDA approval for diabetic cats.

PROZINC makes treatment simple.

Just two daily doses deliver quick and effective results regardless of the diet the cat is fed.2 Plus, PROZINC is for newly diabetic cats and cats who haven't responded well to other treatments and insulin products.2

It's proven safe for cats.

It's proven safe and effective for the reduction of hyperglycemia (high blood glucose) and clinical signs associated with hyperglycemia in cats with diabetes. The safety and efficacy of PROZINC in kittens has not been evaluated.3,4

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IMPORTANT SAFETY INFORMATION

Owners should be advised to look for signs of hypoglycemia. PROZINC is for cats only. PROZINC Insulin, like other drugs, may cause some serious side effects. Serious side effects can occur with or without warning. Please contact your veterinarian immediately if you think your cat has a medical problem or side effect from ProZinc therapy. The most common insulin-related side effect is low blood glucose (hypoglycemia). Signs of hypoglycemia may occur suddenly and can include: weakness, depression, lethargy, sluggishness, staggering gait, behavioral changes, muscle twitching, seizures, coma, death.

Get Clinically Proven Benefits

Learn how PROZINC improves body weight, blood glucose levels and more.3

Reduce Fructosamine LevelsIn a clinical study, diabetic cats showed significant improvement in fructosamine levels within just 45 days on PROZINC.

  • The average fructosamine level dropped from 506 to 381 mol/Lby day 45 and continued to decrease over the next 136 days3, 4
  • Based on fructosamine, 75% of cats were considered to be in good or excellent glycemic control after 181 days of treatment5

In a 45-day effectiveness field study, 176 cats received PROZINC insulin. Hypoglycemia (defined as a blood glucose vale of < 50 mg/dL) occurred in 71 percent of the cats at various times throughout the study. Clinical signs of hypoglycemia were generally mild in nature (described as lethargic, sluggish, weak, trembling, uncoordinated, groggy, glassy-eyed or dazed). See the safety information to learn more.

Reduce Excessive Urination and ThirstIn a clinical study, diabetic cats showed significant improvement in excessive urination and thirst within just 45 days on PROZINC.

PROZINC works fast

About half of the cats in this study showed improvement within seven days.5

By day 45:

  • Excessive urination improved in 74% of cats3
  • Excessive thirst improved in 76% of cats3

IMPORTANT SAFETY INFORMATION: In addition to hypoglycemia, the following clinical observations were reported during the study: vomiting, lethargy, cystitis/hematuria, upper respiratory infection, dry coat, hair loss, ocular discharge, abnormal vocalization, black stool and rapid breathing. See the safety information to learn more.

Improve Body WeightIn a clinical study, diabetic cats showed significant improvement in body condition within just 45 days on PROZINC.2

By day 45:

  • The average body weight of cats on PROZINC increased from 11.9 pounds at the start of the study to 13 pounds2
  • 89% of cats were determined by their veterinarians to be in good body condition2

Reduce Blood Glucose LevelsIn a clinical study, diabetic cats showed significant improvement in blood glucose levels within just 45 days on PROZINC.

By day 45:

  • 74% of cats had an average blood glucose lower than 300 mg/dL5
  • Average blood glucose nadir (daily low) dropped from 408 to 142 mg/dL3, 4

In a 45-day effectiveness field study, 176 cats received PROZINC insulin. Hypoglycemia (defined as a blood glucose vale of < 50 mg/dL) occurred in 71% of the cats at various times throughout the study. Clinical signs of hypoglycemia were generally mild in nature (described as lethargic, sluggish, weak, trembling, uncoordinated, groggy, glassy-eyed or dazed). See the safety information to learn more.

PROZINC Product Information

PROZINC Product Information

What is PROZINC Insulin?

PROZINC insulin is an aqueous protamine zinc suspension of recombinant human insulin that is used to reduce hyperglycemia (high blood glucose or high blood sugar) in cats with diabetes mellitus. A licensed veterinarian must prescribe PROZINC insulin for your cat. PROZINC insulin should be given to cats only. Keep out of reach of children. Seek medical attention immediately if you accidentally inject yourself with PROZINC insulin.

Download full product information (PDF)

Hear From Experts

Hear from Experts

Richard W. Nelson, DVM, DACVIM

University of California, Davis

"The consistent action of a protamine zinc insulin combined with human recombinant technology makes PROZINC an ideal solution for the challenging task of establishing and maintaining good glycemic control in diabetic cats."

Dr. Richard Nelson

Dr. Nelson received his DVM degree from the University of Minnesota in 1979. He completed a small animal internship at Washington State University in 1980 and a small animal medicine residency at the University of California, Davis in 1982. He is a Diplomate of the American College of Veterinary Internal Medicine. Read more

Gary D. Norsworthy, DVM, DABVP (Feline)

Mississippi State University

"With its reliability and long duration of action, PROZINC insulin should soon become the preferred treatment for managing feline diabetes."

Dr. Gary Norsworthy

Dr. Gary D. Norsworthy has been in private practice for 37 years, 25 in small animal practice and 12 in feline practice. He is the owner of Alamo Feline Health Center in San Antonio, Texas. Read more

References

1Nelson RW. Disorders of the Endocrine Pancreas. In: Nelson RW, Couto CG, eds. Small Animal Internal Medicine. 4th ed. St. Louis, MO: Mosby Elsevier; 2008: 764-802.
2Nelson RW, Henley K, Cole C, et al. Field safety and efficacy of protamine zinc recombinant human insulin for treatment of diabetes mellitus in cats. J Vet Intern Med. 2009;23:787-793.
3FOI for NADA 141-297. (PROZINC)
4PROZINC product insert.

5Data on file. St. Joseph, MO: Boehringer Ingelheim Vetmedica,Inc.